Semaphorin 3A inactivation suppresses ischemia-reperfusion-induced inflammation and acute kidney injury
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چکیده
منابع مشابه
Semaphorin 3A inactivation suppresses ischemia-reperfusion-induced inflammation and acute kidney injury.
Recent studies show that guidance molecules that are known to regulate cell migration during development may also play an important role in adult pathophysiologic states. One such molecule, semaphorin3A (sema3A), is highly expressed after acute kidney injury (AKI) in mice and humans, but its pathophysiological role is unknown. Genetic inactivation of sema3A protected mice from ischemia-reperfus...
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BACKGROUND Semaphorin 3A is a secreted protein that regulates cell motility and attachment in axon guidance, vascular growth, immune cell regulation and tumor progression. However, nothing is known about its role in kidney pathophysiology. Here, we determined whether semaphorin3A is induced after acute kidney injury (AKI) and whether urinary semaphorin 3A can predict AKI in humans undergoing ca...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2014
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00177.2014